Low Molecular Weight Heparins : Basic and Applied Considerations
نویسندگان
چکیده
117 During the past decade a large number of new anticoagulant and antithrombotic drugs have been developed. As shown in Fig. 1, these agents represent a wide variety of substances which are derived utilizing natural sources, biotechnology based methods and synthetic approaches.1 Because of the structural and molecular characteristics, these agents exhibit both physicochemical and functional diversities. Thus, each of these classes of drugs control thrombogenesis via distinct mechanisms.
منابع مشابه
Oligosaccharide mapping of low molecular weight heparins: structure and activity differences.
Low molecular weight heparins from a variety of commercial sources were examined. These had been prepared by several methods including peroxidative cleavage, nitrous acid cleavage, chemical beta-elimination, enzymatic beta-elimination, and chromatographic fractionation. The molecular weight and polydispersity of these low molecular weight heparins showed greater differences than were observed f...
متن کاملMolecular weight of low molecular weight heparins by 13C nuclear magnetic resonance spectroscopy.
Heparin and low molecular weight heparins are polydisperse polysaccharides with a degree of polymerization ranging from 4 to approximately 40. The determination of their average molecular weights has traditionally relied on size exclusion chromatography involving the use of oligosaccharides of known size and molecular weight as standards. 13C NMR spectroscopy is applied for the first time to ob...
متن کاملGlycCompSoft: Software for Automated Comparison of Low Molecular Weight Heparins Using Top-Down LC/MS Data
Low molecular weight heparins are complex polycomponent drugs that have recently become amenable to top-down analysis using liquid chromatography-mass spectrometry. Even using open source deconvolution software, DeconTools, and automatic structural assignment software, GlycReSoft, the comparison of two or more low molecular weight heparins is extremely time-consuming, taking about a week for an...
متن کاملPrevention of Venous Thromboembolism in Major Orthopedic Surgery: Bayesian Network Meta-Analysis of 21 Randomized Trials Evaluating Unfractionated Heparins, Low-Molecular Weight Heparins, and New Oral Anticoagulants
Background: In major orthopedic surgery, prevention of venous thromboembolism has been based on Unfractionated Heparins (UFHs) over the past decades, then on LowMolecular Weight Heparins (LMWHs), and on New Oral Anticoagulants (NOACs) more recently. To summarize the comparative effectiveness of UFHs, LMWHs, and NOACs in this clinical indication, we applied Bayesian network meta-analysis to the ...
متن کاملInhibition of allergic airway responses by inhaled low-molecular-weight heparins: molecular-weight dependence.
Inhaled heparin prevents antigen-induced bronchoconstriction and inhibits anti-immunoglobulin E-mediated mast cell degranulation. We hypothesized that the antiallergic action of heparin may be molecular weight dependent. Therefore, we studied the effects of three different low-molecular-weight fractions of heparin [medium-, low-, and ultralow-molecular-weight heparin (MMWH, LMWH, ULMWH, respect...
متن کامل